Held June 7 and 8, 2005
| Round | Pick | Player | Pos. | School | Hometown | Signed |
|---|
| 1 | 13 | Snyder, Brandon | C | Westfield HS | Centreville, VA | Y |
| 1S | 48 | Olson, Garrett | LHP | Cal Poly | | Y |
| 2 | 61 | Reimold, Nolan | OF | Bowling Green State U. | | Y |
| 3 | 93 | Erbe, Brandon | RHP | McDonough School | Baltimore, MD | Y |
| 4 | 123 | Pope, Kieron | OF | East Coweta HS | Gay, GA | Y |
| 5 | 153 | Hamblet, Reid | RHP | Biola U. | | Y |
| 6 | 183 | Owen, Blake | RHP | Belmont (Tenn.) U. | | Y |
| 7 | 213 | Andrews, Bobby | OF | Cal State Fullerton | | Y |
| 8 | 243 | Spoone, Chorye | RHP | Catonsville (Md.) JC | | Y |
| 9 | 273 | Figueroa, Paco | 2B | U. of Miami | | Y |
| 10 | 303 | Stadanlick, Ryan | RHP | St. Joseph's U. | | Y |
| 11 | 333 | Gallaway, Bruce | LHP | Missouri Valley College | | Y |
| 12 | 363 | Raynor, John | OF | UNC Wilmington | | |
| 13 | 393 | Dahlberg, Kyle | C | Texas Christian U. | | Y |
| 14 | 423 | Fleisher, Mark | 1B | Radford U. | | Y |
| 15 | 453 | Kendricks, Brandon | OF | De Soto HS | Ovilla, TX | |
| 16 | 483 | Hernandez, David | RHP | Cosumnes River (Calif.) JC | | Y |
| 17 | 513 | Moore, Jeff | RHP | UNC Wilmington | | Y |
| 18 | 543 | Whitney, Michael | RHP | Cypress-Fairbanks HS | Houston, TX | |
| 19 | 573 | Lidyard, D.J. | RHP | Lower Columbia (Wash.) JC | | |
| 20 | 603 | Steinbach, Ryan | SS | Indiana-Purdue U.-Fort Wayne | | Y |
| 21 | 633 | Logan, Brian | LHP | Louisburg (N.C.) CC | | |
| 22 | 663 | Chmiel, Paul | 1B | Pittston Area HS | Pittston, PA | |
| 23 | 693 | Vargas, Elvin | OF | Connors State (Okla.) JC | | |
| 24 | 723 | Musslewhite, Stuart | SS | Texas Christian U. | | Y |
| 25 | 753 | Lonsberry, Daniel | RHP | Northwestern State U. | | Y |
| 26 | 783 | Hernandez, Carlos | LHP | Santa Clara HS | Santa Clara, CA | |
| 27 | 813 | Thall, Chad | LHP | Jefferson (Mo.) JC | | |
| 28 | 843 | Abreu, Miguel | 2B | East Central (Okla.) U. | | Y |
| 29 | 873 | Scheppers, Tanner | RHP | Dana Hills HS | Laguna Niguel, CA | |
| 30 | 903 | Young, Greg | OF | Anne Arundel (Md.) CC | | Y |
| 31 | 933 | Hempy, Arik | LHP | U. of South Carolina | | |
| 32 | 963 | Faiola, Josh | RHP | Dartmouth College | | |
| 33 | 993 | Anu, Tyrone | OF | Colonial HS | Orlando, FL | |
| 34 | 1023 | Sopic, Matthew | RHP | Seward County (Kan.) CC | | |
| 35 | 1053 | Egan, Patrick | RHP | Quinnipiac U. | | |
| 36 | 1083 | Ferguson, Shawn | RHP | Texas Christian U. | | |
| 37 | 1113 | Foster, Stephen | LHP | Auburn HS | Auburn, WA | |
| 38 | 1143 | Vinyard, Chris | C | Chandler-Gilbert (Ariz.) CC | | |
| 39 | 1173 | Annesley, Caleb | C | Blanchard HS | Blanchard, OK | |
| 40 | 1202 | Bishop, Harrison | RHP | Edmonds (Wash.) CC | | |
| 41 | 1231 | Horner, Mark | LHP | Oklahoma City U. | | Y |
| 42 | 1260 | Lee, Bryan | RHP | Cuesta (Calif.) JC | | |
| 43 | 1289 | Figueroa, Danny | OF | U. of Miami | | |
| 44 | 1318 | Bent, Brian | C | Catonsville (Md.) CC | | |
| 45 | 1347 | Rifkin, Brad | 1B | Park School HS | Columbia, MD | |
| 46 | 1376 | Brian, Benjamin | OF | Wayne HS | Waynesville, OH | |
| 47 | 1405 | Johnson, Craig | RHP | Bellevue (Wash.) CC | | |
| 48 | 1433 | Davis, Brent | RHP | Clear Lake HS | Houston, TX | |
| 49 | 1460 | Saldivar, Ryan | C | Ryan HS | Denton, TX | |
| 50 | 1487 | Bloor, Jeremy | LHP | Grand Rapids (Mich.) CC | | |
